Set during the Muromachi Period (1333-1568) of Japan, Mononoke Hime is a story about a mystic fight between the Animal Gods of the forest and humans.

On the side of the Animal Gods is San (Mononoke Hime), a human girl raised by the wolf god Moro. On the side of the humans is Lady Eboshi, building a kingdom for oppressed people by cutting down the forest for her iron-making operation.

In the middle of this fierce fighting for survival, Ashitaka, an Emishi boy, struggles to find a way for both sides to co-exist. But the fighting just becomes more and more bloody and all hope seems to be lost...